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This Issue
Editorial
July 20, 2023
Cathy J.Bradley,PhD, MPA1; K. RobinYabroff,PhD2; Ya-Chen TinaShih,PhD3,4
Author Affiliations Article Information
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1University of Colorado Comprehensive Cancer Center and Colorado School of Public Health, Aurora
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2Surveillance and Health Equity Science Department, American Cancer Society, Atlanta, Georgia
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3Section of Cancer Economics and Policy, Department of Health Services Research, University of Texas MD Anderson Cancer Center, Houston
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4University of California–Los Angeles Jonsson Comprehensive Cancer Center and UCLA School of Medicine, Los Angeles
JAMA Oncol. 2023;9(9):1202-1204. doi:10.1001/jamaoncol.2023.2226
- Original Investigation Cost of Drug Wastage From Dose Modification and Discontinuation of Oral Anticancer Drugs
MichaelLam,PharmD; TimothéeOlivier,MD; AlysonHaslam,PhD; JordanTuia,BA; VinayPrasad,MD, MPH
JAMA Oncology
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Oral targeted agents for cancer are among the most expensive outpatient prescription drugs dispensed in the US.1 These drugs, often distributed as specialty drugs, can cost more than $170 000 per patient per year.2 Patients in the US pay a greater share of their health care costs than patients living in other developed countries. As a result, terms such as “financial burden,” “financial hardship,” and “financial toxicity” have risen, especially in the US, to describe the untenable phenomenon patients, particularly those treated for cancer, face: treatment can result in long-term financial hardship3 that may be so severe as to result in medical bankruptcy4,5 or inability to complete recommended treatment protocols.6 Moreover, the cost of targeted oral medications for cancer treatment continues to rise. One study7 using Surveillance, Epidemiology, and End Results (SEER)-Medicare data reported that oral prescription drugs for leukemia increased by 27% between 2007 and 2013, reaching $2.35 billion. Another study8 analyzing the SEER-Medicare 5% Cancer File showed that mean 30-day total spending on targeted oral anticancer drugs more than doubled in 5 years, from $4011 in 2011 to $8857 in 2016.
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Targeted and Immune Therapy Oncology Pharmacoeconomics Pharmacoepidemiology
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Bradley CJ, Yabroff KR, Shih YT. Discarded Targeted Oral Anticancer Medication—A Hard Pill to Swallow? JAMA Oncol. 2023;9(9):1202–1204. doi:10.1001/jamaoncol.2023.2226
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